Commentary: IL-4 and IL-13 receptors and signaling
نویسندگان
چکیده
منابع مشابه
Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes.
IL-8 and related Glu-Leu-Arg (ELR+) CXC chemokines are potent chemoattractants for neutrophils but not for monocytes. IL-13 and IL-4 strongly increased CXCR1 and CXCR2 chemokine receptor expression in human monocytes, macrophages, and dendritic cells. The effect was receptor- and cell type-selective, in that CCRs were not increased and no augmentation was seen in neutrophils. The effect was rap...
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immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...
متن کاملAn interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13- induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors
Interleukin 4 (IL-4) and IL-13 share many biological functions. Both cytokines promote growth of activated human B cells and induce naive human surface immunoglobulin D+ (sIgD+) B cells to produce IgG4 and IgE. Here we show that a mutant form of human IL-4, in which the tyrosine residue at position 124 is replaced by aspartic acid (hIL-4.Y124D), specifically blocks IL-4 and IL-13-induced prolif...
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Prevalence of chronic disorder like asthma has dramatically increased in recent decades. These are mainly disorder of immune system, the results of complex interactions among various genetic and environmental factors. Interleukin 4 and 13, a Th2type cytokine play key role in inflammatory pathway, emerged in the pathogenesis of bronchial asthma. Both are act as central regulator in IgE synthesis...
متن کاملExpression of IL-4/IL-13 receptors in differentiating human airway epithelial cells.
IL-4 and IL-13 elicit several important responses in airway epithelium including chemokine secretion and mucous secretion that may contribute to airway inflammation, cell migration, and differentiation. These cytokines have overlapping but not identical effector profiles likely due to shared subunits in their receptor complexes. These receptors are variably described in epithelial cells, and th...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2015
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2015.05.023